Role of protein kinase PLK1 in the epigenetic maintenance of centromeres.
basic_science · Level V
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- Record sourced from PubMed, PMID 39236163.
- Also identified by DOI 10.1126/science.ado5178.
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Abstract
The centromere, a chromosome locus defined by the histone H3-like protein centromeric protein A (CENP-A), promotes assembly of the kinetochore to bind microtubules during cell division. Centromere maintenance requires CENP-A to be actively replenished by dedicated protein machinery in the early G<sub>1</sub> phase of the cell cycle to compensate for its dilution after DNA replication. Cyclin-dependent kinases (CDKs) limit CENP-A deposition to once per cell cycle and function as negative regulators outside of early G<sub>1</sub>. Antithetically, Polo-like kinase 1 (PLK1) promotes CENP-A deposition in early G<sub>1</sub>, but the molecular details of this process are still unknown. We reveal here a phosphorylation network that recruits PLK1 to the deposition machinery to control a conformational switch required for licensing the CENP-A deposition reaction. Our findings clarify how PLK1 contributes to the epigenetic maintenance of centromeres.
Medical subject headings
- Cell Cycle Proteins
- Centromere
- Centromere Protein A
- Chromosomal Proteins, Non-Histone
- Epigenesis, Genetic
- Polo-Like Kinase 1