Deep learning meets histones at the replication fork.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39241742.
- Also identified by DOI 10.1016/j.cell.2024.07.055.
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Abstract
Epigenetic inheritance of heterochromatin requires transfer of parental H3-H4 tetramers to both daughter duplexes during replication. Three recent papers exploit yeast genetics coupled to inheritance assays and AlphaFold2-multimer predictions coupled to biochemistry to reveal that a replisome component (Mrc1/CLASPIN) is an H3-H4 tetramer chaperone important for parental histone transfer to daughters.
Medical subject headings
- DNA Replication
- Histones
- Saccharomyces cerevisiae
- Deep Learning