A one-way street recognition approach to mediate allogeneic immune cell therapies.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 39241752.
- Also identified by DOI 10.1016/j.stem.2024.07.005.
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Abstract
CD54 and CD58 are adhesion proteins that mediate efficient immune synapse formation. Hammer et al. now show that the abrogation of these molecules in T and NK cells prevents their immune rejection while maintaining their effector function. These findings should significantly help advance our efforts to generate "off-the-shelf" allogeneic products.
Medical subject headings
- Killer Cells, Natural