Acetate to the rescue: Acetyl-CoA facilitates placental development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39241753.
- Also identified by DOI 10.1016/j.stem.2024.08.003.
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Abstract
While the placenta regulates nutritional exchange between mother and fetus, Yu et al. reveal that human placental development is itself nutrient-sensitive. They elucidate entwined metabolic and epigenetic transitions driving syncytialization and pinpoint a requirement for the metabolite acetyl-CoA, which is sensitive to glucose metabolism.
Medical subject headings
- Acetyl Coenzyme A
- Placentation
- Placenta