Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn.

Archambault, Jamie L; Hernandez, Teri L; Nozik, Eva S; Palmer, Claire; Dillon, Mairead; Singh, Ravinder J; Galambos, Csaba; Delaney, Cassidy A · J Pediatr · 2025

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Abstract

Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

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