Dynamic Functional Network Connectivity in Acute Incomplete Cervical Cord Injury Patients and Its Associations With Sensorimotor Dysfunction Measures.

Abstract

Dynamic functional network connectivity (dFNC) captures temporal variations in functional connectivity during magnetic resonance imaging acquisition. However, the neural mechanisms driving dFNC alterations in the brain networks of patients with acute incomplete cervical cord injury (AICCI) remain unclear. This study included 16 AICCI patients and 16 healthy controls. Initially, independent component analysis was employed to extract whole-brain independent components from resting-state functional magnetic resonance imaging data. Subsequently, a sliding time window approach, combined with k-means clustering, was used to estimate dFNC states for each participant. Finally, a correlation analysis was conducted to examine the association between sensorimotor dysfunction scores in AICCI patients and the temporal characteristics of dFNC. Independent component analysis was employed to extract 26 whole-brain independent components. Subsequent dynamic analysis identified 4 distinct connectivity states across the entire cohort. Notably, AICCI patients demonstrated a significant preference for State 3 compared to healthy controls, as evidenced by a higher frequency and longer duration spent in this state. Conversely, State 4 exhibited a reduced frequency and shorter dwell time in AICCI patients. Moreover, correlation analysis revealed a positive association between sensorimotor dysfunction and both the mean dwell time and the fraction of time spent in State 3. Patients with AICCI demonstrate abnormal connectivity within dFNC states, and the temporal characteristics of dFNC are associated with sensorimotor dysfunction scores. These findings highlight the potential of dFNC as a sensitive biomarker for detecting network functional changes in AICCI patients, providing valuable insights into the dynamic alterations in brain connectivity related to sensorimotor dysfunction in this population.