H<sub>2</sub>O<sub>2</sub> sulfenylates CHE, linking local infection to the establishment of systemic acquired resistance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39265009.
- Also identified by DOI 10.1126/science.adj7249 and PMC identifier 11586058.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For many years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been debated. We found that in <i>Arabidopsis thaliana</i>, after a local infection, the conserved cysteine residue of the transcription factor CCA1 HIKING EXPEDITION (CHE) undergoes sulfenylation in systemic tissues, which enhances its binding to the promoter of the SA-synthesis gene <i>ISOCHORISMATE SYNTHASE1</i> (<i>ICS1</i>) and increases SA production. Furthermore, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) produced through NADPH oxidases is the mobile signal that sulfenylates CHE in a concentration-dependent manner. Accumulation of SA and the previously reported signal molecules, such as <i>N</i>-hydroxypipecolic acid (NHP), then form a signal amplification loop to establish SAR.
Medical subject headings
- Arabidopsis
- Arabidopsis Proteins
- Hydrogen Peroxide
- Salicylic Acid
- Transcription Factors
- Plant Diseases