Use of Radiation Therapy in the Management of Vulvar Cancers-Identification and Management of Acute and Late Toxicities.

DeCesaris, Cristina; Bedell, Sabrina; Kelley, Kristen; Gaffney, David; Suneja, Gita; Burt, Lindsay; Jarboe, Elke; Brower, Jeffrey · Pract Radiat Oncol · 2025

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Abstract

Radiation therapy plays a critical role in the management of locally advanced vulvar cancers but can lead to a unique spectrum of side effects, with >25% of patients experiencing high-grade toxicities. The treatment phase requires meticulous perineal skincare and may require pharmacologic management of dysuria and cystitis, diarrhea, nausea, and dermatitis/mucositis. The addition of chemotherapy warrants close laboratory monitoring for hematologic and metabolic derangements.

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