Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 39306320.
- Also identified by DOI 10.1016/j.jpeds.2024.114322 and PMC identifier 11645209.
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Abstract
This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.
Medical subject headings
- Extracorporeal Membrane Oxygenation
- Heart Defects, Congenital
- Proteome
- Biomarkers