Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 39322407.
- Also identified by DOI 10.1136/thorax-2024-222026 and PMC identifier 11503173.
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Abstract
Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations.
Medical subject headings
- Community-Acquired Infections
- Mesenchymal Stem Cell Transplantation
- Biomarkers