Mortality associated with clozapine: what is the evidence?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 39354861.
- Also identified by DOI 10.1192/bjp.2024.88.
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Abstract
While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity.
Medical subject headings
- Clozapine
- Antipsychotic Agents
- Schizophrenia