Oxidative stability of chelated Sn(II)<sub>(aq)</sub> at neutral pH: The critical role of NO<sub>3</sub><sup>-</sup> ions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39356766.
- Also identified by DOI 10.1126/sciadv.adq0839 and PMC identifier 11446270.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Tin(II) compounds are versatile materials with applications across fields such as catalysis, diagnostic imaging, and therapeutic drugs. However, oxidative stabilization of Sn(II) has remained an unresolved challenge as its reactivity with water and dioxygen results in loss of functionality, limiting technological advancement. Approaches to slow Sn(II) oxidation with chelating ligands or sacrificial electron donors have yielded only moderate improvements. We demonstrate here that the addition of nitrate to pyrophosphate-chelated Sn(II)<sub>(aq)</sub> suppresses Sn(II) oxidation in water across a broad pH range. Evidence of hydroxyl radical concentration reduction and detection of a radical nitrogen species that only forms in the presence of chelated Sn(II) point to a radical-based reaction mechanism. While this chemistry can be broadly applied, we present that this approach maintains Sn(II)'s antibacterial and anti-inflammatory efficacies as an example of sustained oral chemotherapeutic functionality.