Predicting visual function by interpreting a neuronal wiring diagram.

Abstract

As connectomics advances, it will become commonplace to know far more about the structure of a nervous system than about its function. The starting point for many investigations will become neuronal wiring diagrams, which will be interpreted to make theoretical predictions about function. Here I demonstrate this emerging approach with the Drosophila optic lobe, analysing its structure to predict that three Dm3 (refs. ^1-4) and three TmY (refs. ^2,4) cell types are part of a circuit that serves the function of form vision. Receptive fields are predicted from connectivity, and suggest that the cell types encode the local orientation of a visual stimulus. Extraclassical^5,6 receptive fields are also predicted, with implications for robust orientation tuning⁷, position invariance^8,9 and completion of noisy or illusory contours^10,11. The TmY types synapse onto neurons that project from the optic lobe to the central brain^12,13, which are conjectured to compute conjunctions and disjunctions of oriented features. My predictions can be tested through neurophysiology, which would constrain the parameters and biophysical mechanisms in neural network models of fly vision¹⁴.