Clozapine monitoring requirements: is it time for an update?

Fernandez-Egea, Emilio; McCutcheon, Robert A · Br J Psychiatry · 2025

editorial · Level V

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Abstract

Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.

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