vSPACE: exploring virtual spatial representation of articular chondrocytes at the single-cell level.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39363499.
- Also identified by DOI 10.1093/bioinformatics/btae568 and PMC identifier 11483105.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
vSPACE is a web-based application presenting a spatial representation of scRNAseq data obtained from human articular cartilage by emulating the concept of spatial transcriptomics technology, but virtually. This virtual 2D plot presentation of human articular cartage cells generates several zonal distribution patterns, for one or multiple genes at a time, revealing patterns that scientists can appreciate as imputed spatial distribution patterns along the zonal axis. vSPACE is implemented in Python Dash as a web-based toolbox designed for data visualization of zonal gene expression patterns in articular cartilage chondrocytes. This tool is freely accessible at: https://vspace.cse.uconn.edu/The source code and extra materials for this service can be downloaded from: https://github.com/zhacheny/vSPACE.
Medical subject headings
- Chondrocytes
- Cartilage, Articular
- Software
- Single-Cell Analysis