"Cancer Integrin" α v β 6 Imaging With 68 Ga-Trivehexin PET/CT in Assessment of Ovarian Carcinoma.

Singh, Parneet; Agrawal, Kanhaiyalal; Emerson, Ralph; Baranwal, Abhinav; Patro, P Sai Sradha; Parida, Girish Kumar · Clin Nucl Med · 2024

case_report · Level V

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Abstract

Peritoneal cancer index is an integral parameter for preoperative assessment of peritoneal disease. Current imaging modalities including 18 F-FDG PET/CT, though superior to CT, underestimate the disease extent, mainly due to its high physiological background activity. Novel "cancer integrin" targeting imaging with 68 Ga-trivehexin demonstrates limited physiological activity in the abdomen with superior target-to-background ratio than 18 F-FDG PET/CT. Thus, we describe the first case demonstrating potential utility of novel "cancer integrin" αvβ6 imaging agent 68 Ga-trivehexin for assessment of disease burden in advanced epithelial ovarian cancer.

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