Early human development and stem cell-based human embryo models.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39366361.
- Also identified by DOI 10.1016/j.stem.2024.09.002 and PMC identifier 7617107.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The use of stem cells to model the early human embryo promises to transform our understanding of developmental biology and human reproduction. In this review, we present our current knowledge of the first 2 weeks of human embryo development. We first focus on the distinct cell lineages of the embryo and the derivation of stem cell lines. We then discuss the intercellular crosstalk that guides early embryo development and how this crosstalk is recapitulated in vitro to generate stem cell-based embryo models. We highlight advances in this fast-developing field, discuss current limitations, and provide a vision for the future.
Medical subject headings
- Embryonic Development