Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39368482.
- Also identified by DOI 10.1016/j.xcrm.2024.101764 and PMC identifier 11513832.
- Licence recorded as CC BY-NC-ND.
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Abstract
Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ TCR) reads from 11,000 tumor samples spanning 33 cancer types, utilizing the TRUST4 algorithm. Our findings reveal extensive diversity in γδ TCR clonality and gene expression, underscoring the potential of γδ T cells as prognostic biomarkers in various cancers. We further demonstrate the utility of TCR gamma (TRG) and delta (TRD) gene expression from standard RNA-sequencing (RNA-seq) data. This comprehensive dataset offers a valuable resource for advancing γδ T cell research, with implications for enhanced immunotherapy approaches or alternative therapeutic strategies. Additionally, our centralized database supports translational research into the therapeutic significance of γδ T cells.
Medical subject headings
- Receptors, Antigen, T-Cell, gamma-delta
- Neoplasms