Reduced Red Blood Cell Deformability in Vivax Malaria.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39374370.
- Also identified by DOI 10.1093/infdis/jiae490 and PMC identifier 11911793.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.
Medical subject headings
- Malaria, Vivax
- Erythrocyte Deformability
- Erythrocytes
- Plasmodium vivax