The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39374384.
- Also identified by DOI 10.1073/pnas.2407246121 and PMC identifier 11494350.
- Licence recorded as CC BY-NC-ND.
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Abstract
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
Medical subject headings
- Glymphatic System
- Cerebrospinal Fluid
- Magnetic Resonance Imaging