Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39382992.
- Also identified by DOI 10.1073/pnas.2413619121 and PMC identifier 11494324.
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Abstract
Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.
Medical subject headings
- Chiroptera
- Antibodies, Neutralizing
- Orthomyxoviridae Infections
- Antibodies, Viral