Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39394207.
- Also identified by DOI 10.1038/s41467-024-52640-8 and PMC identifier 11470063.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y<sup>Sry-</sup> chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
Medical subject headings
- Toll-Like Receptor 7
- Mice, Inbred C57BL
- X Chromosome
- Genotype
- Translocation, Genetic
- Y Chromosome