Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39401278.
- Also identified by DOI 10.1161/CIRCULATIONAHA.124.070067 and PMC identifier 11483158.
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Abstract
Aberrant protein aggregation hijacks phosphorylated STATs and decoys the JAK1-STAT pathway to exacerbate proteotoxicity.
Medical subject headings
- Janus Kinase 1
- Signal Transduction