PRMT5: splicing up tolerance.
basic_science · Level V
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- Record sourced from PubMed, PMID 39403925.
- Also identified by DOI 10.1172/JCI185701 and PMC identifier 11473145.
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Abstract
Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance. Using conditional KO mice, the authors showed that thymic deficiency of Prmt5 predisposed mice to developing autoimmune diseases while enhancing antitumor efficacy. These studies provide insight into the role of PRMT5 in shaping the T cell repertoire with implications for the development of therapies.
Medical subject headings
- Protein-Arginine N-Methyltransferases
- Mice, Knockout