Closed-loop neural interfaces for pain: Where do we stand?

Wang, Jing; Chen, Zhe Sage · Cell Rep Med · 2024

review · Level V

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Abstract

Advances in closed-loop neural interfaces and neuromodulation have offered a potentially effective and non-addictive treatment for chronic pain. These interfaces link neural sensors with device outputs to provide temporally precise stimulation. We discuss challenges and trends of state-of-the-art neural interfaces for treating pain in animal models and human pilot trials.

Medical subject headings