The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39418114.
- Also identified by DOI 10.1111/all.16338 and PMC identifier 11804309.
- Licence recorded as CC BY-NC-ND.
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Abstract
IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell in mice evoked only by intranasal administration of IL-4, but not IL-13. IL-4-evoked pathophysiological effects on olfaction is independent of compromised structural integrity of the olfactory neuroepithelium. IL-4-IL-4Rα signaling modulates neuronal crosstalk with immune cells, suggesting a functional link between olfactory impairment and neuroinflammation. Abbreviations: IL, interleukin; KO, knock-out; wk, week; WT, wild-type.
Medical subject headings
- Interleukin-4
- Signal Transduction
- Smell
- Neuroimmunomodulation
- Interleukin-4 Receptor alpha Subunit
- Olfaction Disorders