Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 39422898.
- Also identified by DOI 10.1158/1078-0432.CCR-24-2738.
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Abstract
Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment. See related article by Lanickova et al., p. 164.
Medical subject headings
- Ovarian Neoplasms
- Tertiary Lymphoid Structures
- Tumor Microenvironment