Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39435850.
- Also identified by DOI 10.1093/infdis/jiae521 and PMC identifier 12054726.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Human immunodeficiency virus-exposed but uninfected infants (iHEU) display altered immunity and are at increased risk of infection. We previously reported that iHEU have decreased maternal microchimerism (MMc)-maternal cells transferred to the offspring in utero/during breastfeeding. We quantified MMc in T-cell subpopulations in iHEU and HIV-unexposed infants (iHU) to determine whether a selective deficiency in MMc contributes to altered cellular immunity. Across all infants, MMc levels were highest in CD8+ T cells; however, the level of CD8+ T-cell MMc was lower in iHEU versus iHU. In limited functional studies, we did not identify cytomegalovirus-specific MMc during infant primary infection.
Medical subject headings
- HIV Infections
- CD8-Positive T-Lymphocytes
- Chimerism
- T-Lymphocytes