Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39436737.
- Also identified by DOI 10.1093/infdis/jiae519 and PMC identifier 11911780.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P < .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.
Medical subject headings
- Chlamydia trachomatis
- Antibodies, Neutralizing
- Chlamydia Infections
- Antibodies, Bacterial