Advancing ketamine in the treatment hierarchy for refractory depression.

Nigam, Kabir; King, Franklin; Espi Forcen, Fernando · Br J Psychiatry · 2025

editorial · Level V

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Abstract

Evidence indicates that ketamine is highly effective, has a lower side effect profile and is better tolerated compared to many augmentation strategies for refractory depression. This, combined with data on psychiatric treatment outcome mediators, suggests that earlier intervention with ketamine could improve outcomes for patients suffering from refractory depression.

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