Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39455565.
- Also identified by DOI 10.1038/s41467-024-53635-1 and PMC identifier 11511947.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C-O, C-S, and C-N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules.