Four-factor Prothrombin Complex Concentrate Use for Bleeding Management in Adult Trauma.

Mora, Lidia; Maegele, Marc; Grottke, Oliver; Koster, Andreas; Stein, Philipp; Levy, Jerrold H; Erdoes, Gabor · Anesthesiology · 2025

review · Level V

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Abstract

The clinical use of four-factor prothrombin complex concentrate in adult trauma patients at risk of bleeding is supported by evidence for urgent reversal of oral anticoagulants but is controversial in acquired traumatic coagulopathy.