Metastatic Mucinous Adenocarcinoma of Unknown Origin Showing 68 Ga-DOTATATE Uptake.

Filizoglu, Nuh; Ozguven, Salih; Dede, Fuat; Turoglu, Halil Turgut; Erdil, Tanju Yusuf · Clin Nucl Med · 2025

case_report · Level V

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Abstract

Although the use of 18 F-FDG PET/CT is well established in the evaluation of adenocarcinoma, the performance of 18 F-FDG PET/CT in mucinous adenocarcinoma is not consistent. 68 Ga-DOTATATE uptake can be observed in some non-neuroendocrine tumors as a result of tumor blood flow and somatostatin receptor expression at different levels. For this reason, 68 Ga-DOTATATE PET/CT may have a prospective role in the evaluation of mucinous adenocarcinoma. However, there is no published case of mucinous adenocarcinoma with 68 Ga-DOTATATE uptake. We present a unique case of metastatic mucinous adenocarcinoma of unknown origin on 68 Ga-DOTATATE PET/CT.

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