High Retention and Adherence With Rapid Long-acting Injectable Preexposure Prophylaxis Implementation in an Urban Safety Net Clinic Population.

Spinelli, Matthew A; Bisom-Rapp, Ezra; Heise, Megan J; Camp, Christina; Appa, Ayesha; Liu, Albert Y; Sassaman, Kevin; Shiels, Mary et al. · Clin Infect Dis · 2025

prospective_cohort · Level II

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Abstract

In a low-barrier, long-acting preexposure prophylaxis (PrEP) program in a safety net setting, permitting same-day or next-day initiation, 85% of injections were on time, and 6-month retention was 83%, surpassing outcomes from most previously reported oral PrEP studies. With drop-in, wraparound services, similar retention among housing-insecure populations was seen. Long-acting PrEP expansion is urgently needed.

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