Unearthing a Prostate Cancer cfDNA Signature that "Stems" from AR Alterations.
editorial · Level V
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- Record sourced from PubMed, PMID 39495177.
- Also identified by DOI 10.1158/1078-0432.CCR-24-2849.
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Abstract
Androgen receptor alterations portend a poor prognosis in patients with advanced prostate cancer. A recent study identified a stemness signature enriched in cell-free DNA from androgen receptor-altered patients, associated with worse outcomes. These findings highlight the potential of epigenomic liquid biopsy tools to discover novel clinically relevant tumor molecular subtypes. See related article by Chauhan et al., p. 151.
Medical subject headings
- Prostatic Neoplasms
- Receptors, Androgen
- Biomarkers, Tumor