In symptomatic knee OA, adding oral methotrexate to usual analgesia reduced pain at 6 mo.

Pisetsky, David S · Ann Intern Med · 2024

rct · Level II

Where this comes from

Abstract

Kingsbury SR, Tharmanathan P, Keding A, et al. <b>Pain reduction with oral methotrexate in knee osteoarthritis: a randomized, placebo-controlled clinical trial.</b> Ann Intern Med. 2024;177:1145-1156. 39074374.