Detection of Live Attenuated Measles Virus in the Respiratory Tract Following Subcutaneous Measles-Mumps-Rubella Vaccination.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39504437.
- Also identified by DOI 10.1093/infdis/jiae537 and PMC identifier 11998556.
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Abstract
The live attenuated measles vaccine is extremely effective in preventing measles and induces mucosal immunity in the respiratory tract; however, the mechanism is not known. We show that live attenuated measles virus (LAMV) RNA is frequently detected in the respiratory tract 7-21 days after subcutaneous measles-mumps-rubella (MMR) vaccination in healthy children (n = 5/20) and macaques (n = 6/8). Replicating LAMV was isolated from the lungs of 2 macaques, with no evidence of transmission to unvaccinated individuals. These observations suggest that LAMV in the respiratory tract may play a role in the development of robust mucosal immunity following MMR vaccination.
Medical subject headings
- Measles virus
- Measles-Mumps-Rubella Vaccine
- Respiratory System