GPR56: GPCR as a guardian against ferroptosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39504935.
- Also identified by DOI 10.1016/j.cmet.2024.08.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis-a form of cell death-and effectively mitigate ferroptosis-associated liver damage.
Medical subject headings
- Ferroptosis
- Receptors, G-Protein-Coupled