A sympathetic paradigm shift for the role of NPY in obesity.
basic_science · Level V
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- Record sourced from PubMed, PMID 39504936.
- Also identified by DOI 10.1016/j.cmet.2024.10.010.
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Abstract
Neuropeptide Y (NPY) is a powerful orexigenic factor in the brain. However, mice lacking NPY or NPY receptor Y1 (NPY1R) have minimal changes in basal food intake. In a study published in Nature, Zhu et al.<sup>1</sup> demystify this paradox and show that central and peripheral NPY have antipodal roles in energy homeostasis.
Medical subject headings
- Neuropeptide Y
- Obesity
- Receptors, Neuropeptide Y