Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance.
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- Record sourced from PubMed, PMID 39528554.
- Also identified by DOI 10.1038/s41467-024-54006-6 and PMC identifier 11555230.
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Abstract
Reporting in <i>Nature Communications</i>, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.