False-Positive Radioiodine Uptake Related to Posttraumatic Scab Demonstrated by SPECT/CT in a Patient With Differentiated Thyroid Cancer.

Mostowski, Romane; de Pontville, Michel; Bardet, Stéphane; Ciappuccini, Renaud · Clin Nucl Med · 2025

case_report · Level V

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Abstract

A 20-year-old man with papillary thyroid cancer received a fourth radioiodine regimen to treat 131 I-avid lung metastases. Posttherapeutic whole-body scan revealed focal radioiodine uptake on the anterior region of the left lower limb that was not visible on previous whole-body scan and which suggested skin contamination. Visual examination of the left leg evidenced a posttraumatic scab caused by a fall 2 weeks before. Skin metastasis was ruled out. 131 I SPECT/CT acquisition ruled out bony uptake and confirmed that the skin uptake was related to the superficial scab.

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