Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 39531505.
- Also identified by DOI 10.2337/db24-0485 and PMC identifier 11755682.
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Abstract
There is variability in early-onset autoimmune diabetes presentation in individuals with monogenic autoimmunity; the mechanism(s) underlying this is unclear. We examined whether type 1 diabetes (T1D) polygenic risk contributes to clinical phenotype in monogenic autoimmune diabetes. Individuals with monogenic autoimmune diabetes had higher T1D genetic risk scores compared with control cohorts, driven largely by increased presence of T1D-risk DR3-DQ2 haplotype. Established T1D polygenic risk alleles, particularly class II HLA genes, contribute to clinical presentation in monogenic autoimmunity.
Medical subject headings
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease