Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39535753.
- Also identified by DOI 10.1093/cid/ciae560 and PMC identifier 11912959.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.
Medical subject headings
- Fluoroquinolones
- Mycobacterium tuberculosis
- Antitubercular Agents
- Tuberculosis, Multidrug-Resistant
- Drug Resistance, Bacterial