Increased COX6A2 Promotes Pancreatic β-Cell Apoptosis and Is Suppressed in Diabetic GK Rats After Roux-en-Y Gastric Bypass.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39546664.
- Also identified by DOI 10.2337/db24-0301.
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Abstract
Cytochrome c oxidase subunit 6A2 (COX6A2) expression is increased in diabetic islets. Increased COX6A2 promotes β-cell apoptosis via modulation of cyclophilin D-mediated cytochrome c release from mitochondria to the cytoplasm. Carbohydrate-responsive element-binding protein epigenetically regulates COX6A2 expression in β-cells. Roux-en-Y gastric bypass reduces COX6A2 expression by regulating the glucagon-like peptide 1/cAMP-dependent protein kinase/carbohydrate-responsive element-binding protein signaling pathway.
Medical subject headings
- Gastric Bypass
- Apoptosis
- Insulin-Secreting Cells
- Electron Transport Complex IV
- Diabetes Mellitus, Experimental