From bacterial operons to gene therapy: 50 years of the journal Cell.
review · Level V
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- Record sourced from PubMed, PMID 39547205.
- Also identified by DOI 10.1016/j.cell.2024.10.037.
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Abstract
Recombinant DNA technology has profoundly advanced virtually every aspect of biological and medical sciences, from basic research to biotechnology. Here, I discuss conceptual connections linking fundamental discoveries that were enabled by the technology, advances in the understanding of gene regulation in both prokaryotes and eukaryotes, and the recent FDA-approved CRISPR-based gene therapy for sickle cell anemia and β-thalassemia based on transcriptional derepression.
Medical subject headings
- Anemia, Sickle Cell
- Genetic Therapy
- Operon