Bound by the love for cholesterol: A transporter meets a GPCR.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39547211.
- Also identified by DOI 10.1016/j.cell.2024.10.033.
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Abstract
In a recently published article in Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporter-like domain with a seven-transmembrane GPCR-like domain and elucidates mechanistic insights into cellular regulation of mTORC1 activity.
Medical subject headings
- Cholesterol
- Receptors, G-Protein-Coupled
- Cryoelectron Microscopy