Large-Scale, High-Density MicroLED Array-Based Optogenetic Device for Neural Stimulation and Recording.

Abstract

Optogenetics has emerged as a pivotal tool in neuroscience, enabling precise control of neural activity through light stimulation. However, the current microLED arrays lack sufficient density and scalability. This study proposes an innovative optogenetic device capable of integrating hundreds of microLEDs and electrocorticography (ECOG) electrodes. Individual or multiple microLEDs in the device can be selectively controlled with a custom controller. The light intensity of microLEDs decreases with increasing brain tissue penetration while maintaining a low temperature rise during pulse stimulations. In addition, interference from microLED pulses on ECOG electrode recordings could be alleviated with local mean subtraction data processing. The optogenetic device enables high-quality neural signal recording and triggers a significant enhancement in neural activity following light stimulation. Integration of microLED arrays and ECOG electrodes in the optogenetic device represents a promising advancement in neuroscientific research, providing improved spatial and temporal recording and control over neural activity.