Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39569822.
- Also identified by DOI 10.1021/acs.nanolett.4c04719.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn<sub>1.1</sub>Ga<sub>1.8</sub>Ge<sub>0.1</sub>O<sub>4</sub>:Cr<sup>3+</sup>) and hexagonal-phase upconversion nanoparticles (NaYF<sub>4</sub>:Yb,Tm@NaLuF<sub>4</sub>:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-<i>co</i>-glycolic acid)/<i>N</i>-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth.
Medical subject headings
- Nanoparticles