Immune complex deposition promotes NK cell accumulation in the kidney.
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- Record sourced from PubMed, PMID 39570975.
- Also identified by DOI 10.1371/journal.pone.0312141 and PMC identifier 11581347.
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Abstract
In systemic lupus erythematosus, immune complexes deposited in the kidney vasculature represent a potent inflammatory trigger with a high potential to progress to glomerulonephritis and organ failure. These immune complexes can be recognized by multiple effector cells via complement and Fcγ receptors. The transcriptome of CD16-bearing NK cells has been documented in kidneys from patients with SLE. In this study, we show that NK cells accumulate in the kidney in response to immune complex deposition and modulate the behavior of local T cells. Depletion of NK cells transiently ameliorated disease, suggesting NK cells may play a role in lupus nephritis and other immune complex-mediated conditions.
Medical subject headings
- Killer Cells, Natural
- Kidney
- Antigen-Antibody Complex
- Lupus Nephritis