New insights into mechanisms underlying cognitive impairment in chronic kidney disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39577985.
- Also identified by DOI 10.1016/j.kint.2024.09.008.
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Abstract
Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. Patients with CKD display an increased permeability of the blood-brain barrier. Zimmermann et al. highlighted the implication of potassium efflux in the microglia and its activation, the activation of the interleukin-1b/interleukin-1R pathway, linked to blood-brain barrier permeability and cognitive impairment in CKD. Along with uremic toxicity, this study provides new solid insights about pathophysiological mechanisms of cognitive impairment in CKD, and potential therapeutic targets.
Medical subject headings
- Renal Insufficiency, Chronic
- Blood-Brain Barrier
- Cognitive Dysfunction
- Microglia